Article
A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jan 2016
Dörr Tobias, Alvarez Laura, Delgado Fernanda, Davis Brigid M, Cava Felipe, Waldor Matthew K
Abstract excerpt
The bacterial cell wall is critical for maintenance of cell shape and survival. Following exposure to antibiotics that target enzymes required for cell wall synthesis, bacteria typically lyse. Although several cell envelope stress response systems have been well described, there is little knowledge of systems that modulate cell wall synthesis in response to cell wall damage, particularly in Gram-negative...
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