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Article

Site-specific mutation of Staphylococcus aureus VraS reveals a crucial role for the VraR-VraS sensor in the emergence of glycopeptide resistance.

Antimicrobial agents and chemotherapy - 1 Mar 2011

Galbusera Elena, Renzoni Adriana, Andrey Diego O, Monod Antoinette, Barras Christine, Tortora Paolo, Polissi Alessandra, Kelley William L

Abstract excerpt

An initial response of Staphylococcus aureus to encounter with cell wall-active antibiotics occurs by transmembrane signaling systems that orchestrate changes in gene expression to promote survival. Histidine kinase two-component sensor-response regulators such as VraRS contribute to this response. In this study, we examined VraS membrane sensor phosphotransfer signal transduction and explored the genetic...

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Identifiers

PMID: 21173175
DOI: 10.1128/AAC.00720-10
PMCID: PMC3067069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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