Staphylococcus aureus sensor histidine kinase VraS mutations linked to antibiotic resistance affect enzymatic catalysis, stability, and substrate interactions.

Abstract excerpt

Staphylococcus aureus (S. aureus) is a highly pathogenic bacterium that utilizes the VraSR two-component system to regulate cell wall synthesis and facilitate resistance against antibiotics. Resistant S. aureus isolates were shown to harbor several single-nucleotide polymorphisms in VraS; however, their effect on VraS functionality is not clear. We have investigated the effect of seven mutations in the VraS...

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