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Article

A Close-up View of the VraSR Two-component System

8 Mar 2008

Abstract excerpt

Staphylococcus aureus remains a clinical scourge. Recent studies have revealed that S. aureus is capable of mounting a response to antibiotics that target cell wall peptidoglycan biosynthesis, such as beta-lactams and vancomycin. A phosphotransfer-mediated signaling pathway composed of a histidine protein kinase, VraS, and a response regulator protein, VraR, has been linked to the coordination of this response....

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PMID: 18326495
DOI: 10.1074/jbc.m710010200

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