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The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.

Molecular immunology - 1 May 2020

Babaie Farhad, Hosseinzadeh Ramin, Ebrazeh Mehrdad, Seyfizadeh Narges, Aslani Saeed, Salimi Soraya, Hemmatzadeh Maryam, Azizi Gholamreza, Jadidi-Niaragh Farhad, Mohammadi Hamed

Abstract excerpt

Autoimmunity and cancer affect millions worldwide and both, in principal, result from dysregulated immune responses. There are many well-known molecules involved in immunological process playing as a double-edged sword, by which associating autoimmune diseases and cancer. In this regard, Endoplasmic reticulum aminopeptidases (ERAP) 1, which belongs to the M1 family of aminopeptidases, plays a central role as a...

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PMID: 32135401
DOI: 10.1016/j.molimm.2020.02.020

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