Article
A Lack of Significant Effect of POR*28 Allelic Variant on Tacrolimus Exposure in Kidney Transplant Recipients.
Therapeutic drug monitoring - 1 Apr 2016
Jannot Anne-Sophie, Vuillemin Xavier, Etienne Isabelle, Buchler Mathias, Hurault de Ligny Bruno, Choukroun Gabriel, Colosio Charlotte, Thierry Antoine, Vigneau Cécile, Moulin Bruno, Rerolle Jean-Philippe, Heng Anne-Elizabeth, Subra Jean-Francois, Legendre Christophe, Beaune Philippe, Loriot Marie Anne, Thervet Eric, Pallet Nicolas
Abstract excerpt
BACKGROUND: POR*28 is a recently newly described allelic variant of the cytochrome P450 oxidoreductase (POR), which might be associated with an increased metabolic activity of P450 cytochromes (CYP) 3A5 and 3A4. Consequently, carriers of at least 1 allele of this polymorphism could require increased calcineurin inhibitors doses to reach the target residual concentrations (C0). The objective of this study was to...
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