Article
Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients.
Therapeutic drug monitoring - 1 Feb 2014
Elens Laure, Hesselink Dennis A, Bouamar Rachida, Budde Klemens, de Fijter Johannes W, De Meyer Martine, Mourad Michel, Kuypers Dirk R J, Haufroid Vincent, van Gelder Teun, van Schaik Ron H N
Abstract excerpt
BACKGROUND: The P450 oxidoreductase (POR)*28 variant allele has been associated with altered cytochrome P450 3A enzyme activities. Both CYP3A5 and CYP3A4 are involved in the metabolism of calcineurin inhibitors and recent data show that POR*28 may explain part of the variability observed in tacrolimus (Tac) pharmacokinetics. The aim of this study was to investigate the impact of the POR*28 allele on Tac and...
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