Article
Kidney transplant recipients carrying the CYP3A4*22 allelic variant have reduced tacrolimus clearance and often reach supratherapeutic tacrolimus concentrations.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Mar 2015
Pallet N, Jannot A-S, El Bahri M, Etienne I, Buchler M, de Ligny B H, Choukroun G, Colosio C, Thierry A, Vigneau C, Moulin B, Le Meur Y, Heng A-E, Subra J-F, Legendre C, Beaune P, Alberti C, Loriot M A, Thervet E
Abstract excerpt
CYP3A4*22 is an allelic variant of the cytochrome P450 3A4 associated with a decreased activity. Carriers of this polymorphism may require reduced tacrolimus (Tac) doses to reach the target residual concentrations (Co). We tested this hypothesis in a population of kidney transplant recipients extracted from a multicenter, prospective and randomized study. Among the 186 kidney transplant recipients included, 9.3%...
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