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Article

Impairments in impulse control in mice transgenic for the human FTDP-17 tauV337M mutation are exacerbated by age.

Human molecular genetics - 15 Jul 2007

Lambourne Sarah L, Humby Trevor, Isles Anthony R, Emson Piers C, Spillantini Maria G, Wilkinson Lawrence S

Abstract excerpt

Abnormalities in microtubule-associated tau protein are a key neuropathological feature of both Alzheimer's disease and many frontotemporal dementias (FTDs), including hereditary FTD with Parkinsonism linked to chromosome 17 (FTDP-17). In these disorders, tau becomes aberrantly phosphorylated, le...

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PMID: 17517691
DOI: 10.1093/hmg/ddm119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17517691-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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