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Distinctive age-related temporal cortical thinning in asymptomatic granulin gene mutation carriers.

Neurobiology of aging - 1 May 2013

Moreno Fermín, Sala-Llonch Roser, Barandiaran Myriam, Sánchez-Valle Raquel, Estanga Ainara, Bartrés-Faz David, Sistiaga Andone, Alzualde Ainhoa, Fernández Esther, Martí Massó José Félix, López de Munain Adolfo, Indakoetxea Begoña

Abstract excerpt

Studies in asymptomatic granulin gene (GRN) mutation carriers are essential to improve our understanding of the pattern and timing of early morphologic brain changes in frontotemporal lobar degeneration. The main objectives of this study were to assess the effect of age in cortical thickness changes (CTh) in preclinical GRN mutation carriers and to study the relationship of CTh with cognitive performance in GRN...

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Aged
Aging
Cerebral Cortex
Frontotemporal Lobar Degeneration
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intercellular Signaling Peptides and Proteins

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PMID: 23218900
DOI: 10.1016/j.neurobiolaging.2012.11.005

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GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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