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Article

BRCA1-hapoinsufficiency: Unraveling the molecular and cellular basis for tissue-specific cancer.

Cell cycle (Georgetown, Tex.) - 1 Jan 2016

Sedic Maja, Kuperwasser Charlotte

Abstract excerpt

Over the past 20 years tremendous progress has been made in understanding the function of BRCA1 gene products. Yet one question still remains: why is mutation of BRCA1 typically associated with preferential development of breast and ovarian cancers and not tumors in other tissues? Here we discuss recent evidence documenting the effect of BRCA1-haploinsufficiency in different cells and tissues and synthesize a...

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Share to BRCA1 Protein
Share to Breast Neoplasms
Share to Genes, BRCA1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haploinsufficiency

Share to Mammary Glands, Human

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Source

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Identifiers

PMID: 26822887
DOI: 10.1080/15384101.2016.1141841
PMCID: PMC4845926

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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