Article
Why are Some Tissues More Vulnerable? Revisiting Tissue Specificity in Hereditary Cancer Syndromes.
Molecular diagnosis & therapy - 1 Jul 2026
Kozak Vanessa N, Oliveira Jaqueline C, Gradia Daniela F, Mathias Carolina, Ribeiro Enilze M S F
Abstract excerpt
The genomic era revolution has significantly enhanced our understanding of hereditary cancer predisposition syndromes (HCPSs). However, despite the identification of pathogenic variants in cancer predisposition genes such as RB1, TP53, BRCA1, and BRCA2 and mismatch repair genes as the molecular explanations for familial clustering of specific cancer types, the biological basis behind the striking tissue...
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