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Article

Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.

Annual review of pathology - 1 Jan 2009

Venkitaraman Ashok R

Abstract excerpt

Single-gene disorders that predispose to cancer afford a unique window into the mechanisms of carcinogenesis. I argue that the instability in chromosome structure and number provoked by inactivation of the breast cancer-susceptibility genes BRCA1 and BRCA2 arises from the distinct functions served by their products in DNA repair or mitosis, explains many features of cancer pathogenesis in this setting, and has...

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Source

Identifiers

PMID: 18954285
DOI: 10.1146/annurev.pathol.3.121806.151422

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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