Article
Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.
Nature communications - 24 Jun 2015
Sedic Maja, Skibinski Adam, Brown Nelson, Gallardo Mercedes, Mulligan Peter, Martinez Paula, Keller Patricia J, Glover Eugene, Richardson Andrea L, Cowan Janet, Toland Amanda E, Ravichandran Krithika, Riethman Harold, Naber Stephen P, Näär Anders M, Blasco Maria A, Hinds Philip W, Kuperwasser Charlotte
Abstract excerpt
Although BRCA1 function is essential for maintaining genomic integrity in all cell types, it is unclear why increased risk of cancer in individuals harbouring deleterious mutations in BRCA1 is restricted to only a select few tissues. Here we show that human mammary epithelial cells (HMECs) from BRCA1-mutation carriers (BRCA1(mut/+)) exhibit increased genomic instability and rapid telomere erosion in the absence...
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