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Article

Role of BRCA gene dysfunction in breast and ovarian cancer predisposition.

Breast cancer research : BCR - 1 Jan 2000

Scully R

Abstract excerpt

Tumor suppressor genes that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are mutated in the germline. The two major hereditary breast/ovarian cancer predisposition genes, BRCA1 and BRCA2, appear to participate in a common pathway that is involved in the control of homologous recombination and in the maintenance of genomic integrity....

Read the complete abstract on PubMed

Topics

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Share to BRCA1 Protein
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Share to Cell Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Germ-Line Mutation

Share to Neoplasm Proteins

Share to Ovarian Neoplasms

Share to Recombination, Genetic

Source

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Identifiers

PMID: 11250724
DOI: 10.1186/bcr76
PMCID: PMC138653

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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