Article
Genetic heterogeneity in breast cancer susceptibility.
Acta oncologica (Stockholm, Sweden) - 1 Jan 1996
Andersen T I
Abstract excerpt
Approximately 20% of breast cancer patients have a family history of the disease, and in one-fourth of these cases breast cancer appears to be inherited as an autosomally dominant trait. Five genes and gene regions involved in breast cancer susceptibility have been uncovered. Germ-line mutations in the recently cloned BRCA1 gene at 17q21 is considered to be responsible for the disease in a majority of the...
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