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Article

Revisiting tissue specificity of germline cancer predisposing mutations.

Nature reviews. Cancer - 1 Feb 2015

Maris John M, Knudson Alfred G

Abstract excerpt

Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults?

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Identifiers

PMID: 25688405
DOI: 10.1038/nrc3894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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