Article
Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response.
Nature communications - 29 Jan 2016
Thornton Tina M, Delgado Pilar, Chen Liang, Salas Beatriz, Krementsov Dimitry, Fernandez Miriam, Vernia Santiago, Davis Roger J, Heimann Ruth, Teuscher Cory, Krangel Michael S, Ramiro Almudena R, Rincón Mercedes
Abstract excerpt
Variable, diversity and joining (V(D)J) recombination and immunoglobulin class switch recombination (CSR) are key processes in adaptive immune responses that naturally generate DNA double-strand breaks (DSBs) and trigger a DNA repair response. It is unclear whether this response is associated with distinct survival signals that protect T and B cells. Glycogen synthase kinase 3β (GSK3β) is a constitutively active...
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