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Article

The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect.

Cell reports - 24 Oct 2017

Hewitt Susannah L, Wong Jason B, Lee Ji-Hoon, Nishana Mayilaadumveettil, Chen Hongxi, Coussens Marc, Arnal Suzzette M, Blumenberg Lili M, Roth David B, Paull Tanya T, Skok Jane A

Abstract excerpt

Many DNA lesions associated with lymphoid malignancies are linked to off-target cleavage by the RAG1/2 recombinase. However, off-target cleavage has mostly been analyzed in the context of DNA repair defects, confounding any mechanistic understanding of cleavage deregulation. We identified a conserved SQ phosphorylation site on RAG2 365 to 366 that is involved in feedback control of RAG cleavage. Mutation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29069605
DOI: 10.1016/j.celrep.2017.09.084
PMCID: PMC5662208

Genes

ATM
RAG2
RAG1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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