Article

PKCδ Protects Against Lupus Autoimmunity

2024-04-16

Abstract excerpt

Protein Kinase C delta (PKCδ) has emerged as a key protective molecule against systemic lupus erythematosus (SLE or lupus), an autoimmune disease characterized by anti-double stranded (ds) DNA IgGs. Although PKCδ deficient mice and lupus patients with mutated PRKCD genes clearly demonstrate the requirement of PKCδ for preventing lupus autoimmunity, this critical tolerance mechanism remains poorly understood. We re...

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Literature Corpus work: 60742919-5cfa-512a-9699-1823d92325ea
DOI: 10.20944/preprints202404.1053.v1

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