Article
The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements.
The Journal of experimental medicine - 11 Feb 2013
Steinel Natalie C, Lee Baeck-Seung, Tubbs Anthony T, Bednarski Jeffrey J, Schulte Emily, Yang-Iott Katherine S, Schatz David G, Sleckman Barry P, Bassing Craig H
Abstract excerpt
Allelic exclusion is enforced through the ability of antigen receptor chains expressed from one allele to signal feedback inhibition of V-to-(D)J recombination on the other allele. To achieve allelic exclusion by such means, only one allele can initiate V-to-(D)J recombination within the time required to signal feedback inhibition. DNA double-strand breaks (DSBs) induced by the RAG endonuclease during V(D)J...
Topics
- Adaptor Proteins, Signal Transducing
- Alleles
- Animals
- Ataxia Telangiectasia Mutated Proteins
- B-Lymphocytes
- Base Sequence
- Cell Cycle Proteins
- DNA Breaks, Double-Stranded
- DNA-Binding Proteins