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Article

Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2016

Castranova Daniel, Davis Andrew E, Lo Brigid D, Miller Mayumi F, Paukstelis Paul J, Swift Matthew R, Pham Van N, Torres-Vázquez Jesús, Bell Kameha, Shaw Kenna M, Kamei Makoto, Weinstein Brant M

Abstract excerpt

OBJECTIVE: Understanding the mechanisms regulating normal and pathological angiogenesis is of great scientific and clinical interest. In this report, we show that mutations in 2 different aminoacyl-transfer RNA synthetases, threonyl tRNA synthetase (tars(y58)) or isoleucyl tRNA synthetase (iars(y68)), lead to similar increased branching angiogenesis in developing zebrafish. APPROACH AND RESULTS: The unfolded...

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Identifiers

PMID: 26821951
DOI: 10.1161/ATVBAHA.115.307087
PMCID: PMC4808418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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