Transcriptional and Post-Transcriptional Regulation of Proangiogenic Factors by the Unfolded Protein Response

Abstract excerpt

BACKGROUND: Inadequate extracellular conditions can adversely affect the environment of the ER and impinge on the maturation of nascent proteins. The resultant accumulation of unfolded proteins activates a signal transduction pathway, known as the unfolded protein response, which serves primarily to protect the cell during stress and helps restore homeostasis to the ER. PRINCIPAL FINDINGS: Microarray analysis of...

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