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Redirecting full-length FLT1 expression towards its soluble isoform promotes postischemic angiogenesis

2024-09-20

Abstract excerpt

Vascular endothelial growth factors and their tyrosine kinase receptors are key mediators of vasculogenesis and angiogenesis with FLT1 (VEGFR1) serving as a decoy receptor. A truncated mRNA transcript encoding soluble (s) FLT1 can be generated by premature cleavage and polyadenylation (APA). Although a shortening of transcripts is described in pathological settings, including heart diseases, the functional in vivo...

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Literature Corpus work
d0be29f8-2d60-5fba-840d-b66d4813ec5a
DOI
10.1101/2024.09.19.613989
Open publication

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Redirecting full-length FLT1 expression towards its soluble isoform promotes postischemic angiogenesisDOI 10.1101/2024.09.19.613989
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