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Article

Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway

5 Mar 2010

Abstract excerpt

BACKGROUND: Angiogenesis is crucial to many physiological and pathological processes including development and cancer cell survival. Vascular endothelial growth factor-A (VEGFA) is the predominant mediator of angiogenesis in the VEGF family. During development, adverse environmental conditions like nutrient deprivation, hypoxia and increased protein secretion occur. IRE1alpha, PERK, and ATF6alpha, master...

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PMID: 20221394
DOI: 10.1371/journal.pone.0009575

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