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Article

Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis

21 Feb 2013

Abstract excerpt

Aminoacyl-tRNA synthetases classically regulate protein synthesis but some also engage in alternative signaling functions related to immune responses and angiogenesis. Threonyl-tRNA synthetase (TARS) is an autoantigen in the autoimmune disorder myositis, and borrelidin, a potent inhibitor of TARS, inhibits angiogenesis. We explored a mechanistic link between these findings by testing whether TARS directly affects...

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PMID: 23425968
DOI: 10.1038/srep01317

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