Article
Noncanonical function of threonyl-tRNA synthetase regulates vascular development in zebrafish.
Biochemical and biophysical research communications - 22 Apr 2016
Cao Zigang, Wang Hongcheng, Mao Xiaoyu, Luo Lingfei
Abstract excerpt
The canonical functions of Aminoacyl-tRNA synthetases (AARSs) are indispensable for protein synthesis. However, recent evidence indicates that some AARSs possess additional biological functions (noncanonical functions) related to immune responses and vascular development. Here, we identified a zebrafish cq16 mutant presenting the disorganized vessels with abnormal branching of the established intersegmental...
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