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Article

Modulation of angiogenesis by genetic manipulation of ATF4 in mouse model of oxygen-induced retinopathy [corrected].

Investigative ophthalmology & visual science - 3 Sept 2013

Wang Xiaoqin, Wang Guibo, Kunte Mansi, Shinde Vishal, Gorbatyuk Marina

Abstract excerpt

PURPOSE: The activation of the unfolded protein response (UPR) and an increase in activating transcription factor 4 (ATF4) has been previously reported in the diabetic retina. Despite this, a direct link between ATF4 and the degree of proliferative retinopathy has not been demonstrated to date. Therefore, the objective of this study was to determine whether ATF4 deficiency could reduce neovascularization in mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Stress

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Source

Open in PubMed Open full text

Identifiers

PMID: 23942974
DOI: 10.1167/iovs.13-12117
PMCID: PMC3762331

Genes

ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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