Article
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study.
Journal of the American College of Cardiology - 2 Feb 2016
Keenan Tanya, Zhao Wei, Rasheed Asif, Ho Weang K, Malik Rainer, Felix Janine F, Young Robin, Shah Nabi, Samuel Maria, Sheikh Nasir, Mucksavage Megan L, Shah Omar, Li Jin, Morley Michael, Laser Annika, Mallick Nadeem Hayat, Zaman Khan Shah, Ishaq Mohammad, Rasheed Syed Zahed, Memon Fazal-Ur-Rehman, Ahmed Faisal, Hanif Bashir, Lakhani Muhammad Shakir, Fahim Muhammad, Ishaq Madiha, Shardha Naresh Kumar, Ahmed Naveeduddin, Mahmood Khalid, Iqbal Waseem, Akhtar Saba, Raheel Rabia, O'Donnell Christopher J, Hengstenberg Christian, März Winifred, Kathiresan Sekar, Samani Nilesh, Goel Anuj, Hopewell Jemma C, Chambers John, Cheng Yu-Ching, Sharma Pankaj, Yang Qiong, Rosand Jonathan, Boncoraglio Giorgio B, Kazmi Shahana Urooj, Hakonarson Hakon, Köttgen Anna, Kalogeropoulos Andreas, Frossard Philippe, Kamal Ayeesha, Dichgans Martin, Cappola Thomas, Reilly Muredach P, Danesh John, Rader Daniel J, Voight Benjamin F, Saleheen Danish
Abstract excerpt
BACKGROUND: Although epidemiological studies have reported positive associations between circulating urate levels and cardiometabolic diseases, causality remains uncertain. OBJECTIVES: Through a Mendelian randomization approach, we assessed whether serum urate levels are causally relevant in type 2 diabetes mellitus (T2DM), coronary heart disease (CHD), ischemic stroke, and heart failure (HF). METHODS: This study...
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