Interleukin-6 promoter polymorphism interacts with pain and life stress influencing depression phenotypes.

doi:10.1007/s00702-016-1506-9

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Article

Interleukin-6 promoter polymorphism interacts with pain and life stress influencing depression phenotypes.

Journal of neural transmission (Vienna, Austria : 1996) - 1 May 2016

Kovacs David, Eszlari Nora, Petschner Peter, Pap Dorottya, Vas Szilvia, Kovacs Peter, Gonda Xenia, Bagdy Gyorgy, Juhasz Gabriella

Abstract excerpt

Interleukin-6 (IL-6) has emerged as a potent biomarker for depression as its elevated plasma levels in patients with clinical depression have been confirmed by meta-analyses. Increased plasma IL-6 concentration was associated with various psychological stress factors and physical disorders accompanied by pain. Another modulator of the IL-6 level is rs1800795, a promoter polymorphism in the IL-6 gene which is able...

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Identifiers

PMID: 26821321
DOI: 10.1007/s00702-016-1506-9
PMCID: PMC4846685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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