Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort.

doi:10.1016/j.bbi.2017.11.020

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Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort.

Brain, behavior, and immunity - 1 Mar 2018

Khandaker Golam M, Zammit Stanley, Burgess Stephen, Lewis Glyn, Jones Peter B

Abstract excerpt

OBJECTIVE: Interleukin 6 (IL-6) levels are commonly elevated in patients with depression and psychosis and in people who are at risk of developing these disorders. A common, functional variant in the IL6R gene (IL6R Asp358Ala; rs2228145 A > C) is known to dampen down inflammation by impairing IL6R signaling. We have examined the association of Asp358Ala with diagnosis of depression and psychosis, serum IL-6, CRP...

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PMID: 29197507
DOI: 10.1016/j.bbi.2017.11.020
PMCID: PMC5871397

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