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Article

Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth.

Brain, behavior, and immunity - 1 May 2015

Tartter Margaret, Hammen Constance, Bower Julienne E, Brennan Patricia A, Cole Steven

Abstract excerpt

AIMS: Close to one third of patients with major depression show increases in pro-inflammatory cytokines, which are in turn associated with risk for inflammatory disease. Genetic variants that enhance immune reactivity may thus enhance inflammatory and depressive reactions to stress. The aim of the present study was to investigate a trio of functional SNPs in the promoter regions of IL6 (-174G>C, rs1800795), IL1β...

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Depression
Gene-Environment Interaction
Interleukin-1beta
Interleukin-6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interpersonal Relations

Psychiatric Status Rating Scales

Stress, Psychological

Tumor Necrosis Factor-alpha

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Identifiers

PMID: 25596176
DOI: 10.1016/j.bbi.2015.01.003
PMCID: PMC4515110

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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