Article
Polymorphisms and haplotype of ROCK2 associate with high altitude essential hypertension in native high altitude Ladakhi Indian population: a preliminary study.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2016
Pandey Priyanka, Mohammad Ghulam, Singh Yogendra, Pasha M A Qadar
Abstract excerpt
BACKGROUND AND OBJECTIVES: High-altitude essential hypertension (HAEH) is a disease occurring in permanent residents of high-altitude regions. The disease is characterized with SBP ≥140 mmHg and DBP ≥90 mmHg. HAEH is known to run in families, i.e. the disease has genetic component. Rho-associated coiled-coil containing protein kinase 2 (ROCK2) is a stress-activated serine-threonine kinase known to disturb...
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