Article
A major haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: the HYPGENE study.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Aug 2008
Rankinen Tuomo, Church Timothy, Rice Treva, Markward Nathan, Blair Steven N, Bouchard Claude
Abstract excerpt
The goals of our study were to evaluate the haplotype pattern at the Rho-associated kinase 2 (ROCK2) locus and prospectively test the association between the ROCK2 haplotype-tagging single-nucleotide polymorphisms (tagSNPs) with hypertension for verified incident hypertensive patients (n=607) and healthy, normotensive controls (n=586) in a HYPGENE study. Rho-associated kinases (ROCKs) play a central role in...
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