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Article

Two functional polymorphisms of ROCK2 enhance arterial stiffening through inhibiting its activity and expression.

Journal of molecular and cellular cardiology - 1 Feb 2015

Liao Yi-Chu, Liu Ping-Yen, Lin Hsiu-Fen, Lin Wen-Yi, Liao James K, Juo Suh-Hang H

Abstract excerpt

Derangement of Rho-associated kinases (ROCKs) has been related to coronary artery disease and stroke. ROCK2, rather than ROCK1, plays a predominant role in vascular contractility. The present study aims to test (1) the associations between ROCK2 single nucleotide polymorphisms (SNPs) and arterial stiffness, and (2) the molecular mechanism accounting for their effects. Stiffness parameters including beta (β),...

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Source

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Identifiers

PMID: 25481646
DOI: 10.1016/j.yjmcc.2014.11.023
PMCID: PMC4889447

Genes

ROCK2
ROCK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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