Article
Unique mutations in mitochondrial DNA and associated pathways involved in high altitude pulmonary edema susceptibility in Indian lowlanders.
Journal of biomolecular structure & dynamics - 1 Jul 2023
Sharma Swati, Sandhir Rajat, Ganju Lilly, Kumar Bhuvnesh, Singh Yamini
Abstract excerpt
High altitude pulmonary edema (HAPE) is a life threatening non-cardiogenic pulmonary edema that occurs in an otherwise healthy individuals travelling to altitude above 2500 m. Earlier studies have reported association of mutations in nuclear (nDNA) and mitochondrial DNA (mtDNA) with HAPE susceptibility. However, the molecular mechanisms involved in the pathobiology of HAPE have not been fully understood. The...
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