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Article

Involvement of neuronal cannabinoid receptor CB1 in regulation of bone mass and bone remodeling.

Molecular pharmacology - 1 Sept 2006

Tam Joseph, Ofek Orr, Fride Ester, Ledent Catherine, Gabet Yankel, Müller Ralph, Zimmer Andreas, Mackie Ken, Mechoulam Raphael, Shohami Esther, Bab Itai

Abstract excerpt

The CB1 cannabinoid receptor has been implicated in the regulation of bone remodeling and bone mass. A high bone mass (HBM) phenotype was reported in CB1-null mice generated on a CD1 background (CD1(CB1-/-) mice). By contrast, our preliminary studies in cb1-/- mice, backcrossed to C57BL/6J mice (C57(CB1-/-) mice), revealed low bone mass (LBM). We therefore analyzed CB1 expression in bone and compared the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16772520
DOI: 10.1124/mol.106.026435

Genes

HBM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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