Identification of IRX1 as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis in a Genome-Wide Association Study.

doi:10.1002/art.39591

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Article

Identification of IRX1 as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis in a Genome-Wide Association Study.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2016

Julià Antonio, Blanco Francisco, Fernández-Gutierrez Benjamín, González Antonio, Cañete Juan D, Maymó Joan, Alperi-López Mercedes, Olivè Alex, Corominas Héctor, Martínez-Taboada Víctor, González-Álvaro Isidoro, Fernandez-Nebro Antonio, Erra Alba, Sánchez-Fernández Simón, Alonso Arnald, López-Lasanta María, Tortosa Raül, Codó Laia, Lluis Gelpi Josep, García-Montero Andrés C, Bertranpetit Jaume, Absher Devin, Myers Richard M, Tornero Jesús, Marsal Sara

Abstract excerpt

OBJECTIVE: Rheumatoid factor (RF) is a well-established diagnostic and prognostic biomarker in rheumatoid arthritis (RA). However, ∼20% of RA patients are negative for this anti-IgG antibody. To date, only variation at the HLA-DRB1 gene has been associated with the presence of RF. This study was undertaken to identify additional genetic variants associated with RF positivity. METHODS: A genome-wide association...

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PMID: 26815016
DOI: 10.1002/art.39591

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IRX1

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