Article
Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis.
Rheumatology (Oxford, England) - 1 Dec 2008
Harney S M J, Vilariño-Güell C, Adamopoulos I E, Sims A-M, Lawrence R W, Cardon L R, Newton J L, Meisel C, Pointon J J, Darke C, Athanasou N, Wordsworth B P, Brown M A
Abstract excerpt
OBJECTIVES: The heritability of RA has been estimated to be approximately 55%, of which the MHC contributes about one-third. HLA-DRB1 alleles are strongly associated with RA, but it is likely that significant non-DRB1 MHC genetic susceptibility factors are involved. Previously, we identified two...
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