The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1.

doi:10.1242/dev.132985

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Article

The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1.

Development (Cambridge, England) - 1 Mar 2016

Mariani Luca, Lussi Yvonne C, Vandamme Julien, Riveiro Alba, Salcini Anna Elisabetta

Abstract excerpt

The dynamic regulation of histone modifications is important for modulating transcriptional programs during development. Aberrant H3K4 methylation is associated with neurological disorders, but how the levels and the recognition of this modification affect specific neuronal processes is unclear. Here, we show that RBR-2, the sole homolog of the KDM5 family of H3K4me3/2 demethylases in Caenorhabditis elegans,...

Topics

Actins
Alleles
Animals
Axons
Body Patterning
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Catalysis
Chromatin
Chromosomal Proteins, Non-Histone
Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Developmental

Histone Demethylases

Histones

Lysine

Methylation

Microscopy, Fluorescence

Mutation

Source

Open in PubMed

Identifiers

PMID: 26811384
DOI: 10.1242/dev.132985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26811384-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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