Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caenorhabditis elegans dosage compensation regulates histone H4 chromatin state on X chromosomes.

Molecular and cellular biology - 1 May 2012

Wells Michael B, Snyder Martha J, Custer Laura M, Csankovszki Gyorgyi

Abstract excerpt

Dosage compensation equalizes X-linked gene expression between the sexes. This process is achieved in Caenorhabditis elegans by hermaphrodite-specific, dosage compensation complex (DCC)-mediated, 2-fold X chromosome downregulation. How the DCC downregulates gene expression is not known. By analyzing the distribution of histone modifications in nuclei using quantitative fluorescence microscopy, we found that H4K16...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromatin

Share to SET gene

Share to Histone-Lysine N-Methyltransferase

Share to Histones

Share to Mutation

Share to X Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 22393255
DOI: 10.1128/MCB.06546-11
PMCID: PMC3347233

Genes

DCC
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caenorhabditis elegans dosage compensation regulates histone H4 chromatin state on X chromosomes.PMID 22393255Read ↗

Developmental Dynamics of X-Chromosome Dosage Compensation by the DCC and H4K20me1 in C. elegans.Semantic proximity Read ↗

Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase.Semantic proximity Read ↗

Mechanisms of sex determination and X-chromosome dosage compensationSemantic proximity Read ↗

Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila.Semantic proximity Read ↗

A molecular link between gene-specific and chromosome-wide transcriptional repression.Semantic proximity Read ↗

Condensin IDC has a functional ATPase that is required for X-Chromosome dosage compensation in C. elegans.Semantic proximity Read ↗

Genome-wide analysis of condensin binding in Caenorhabditis elegans.Semantic proximity Read ↗

Dosage compensation proteins targeted to X chromosomes by a determinant of hermaphrodite fate.Semantic proximity Read ↗

Dosage compensation of the sex chromosomes.Semantic proximity Read ↗

Unexpected role for dosage compensation in the control of dauer arrest, insulin-like signaling, and FoxO transcription factor activity in Caenorhabditis elegans.Semantic proximity Read ↗

KDM6A facilitates Xist upregulation at the onset of X inactivationSemantic proximity Read ↗

Dosage compensation in Bombyx mori is achieved by partial repression of both Z chromosomes in malesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.