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The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

30 Aug 2010

Abstract excerpt

Cells respond to ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) by orchestrating events that coordinate cell cycle progression and DNA repair. How cells signal and repair DSBs is not yet fully understood. A genome-wide RNA interference screen in Caenorhabditis elegans identified egr-1 as a factor that protects worm cells against IR. The human homologue of egr-1, MTA2 (metastasis-associated...

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PMID: 20805320
DOI: 10.1083/jcb.201001048

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