Article
The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination.
Development (Cambridge, England) - 1 Dec 2000
von Zelewsky T, Palladino F, Brunschwig K, Tobler H, Hajnal A, Müller F
Abstract excerpt
The Mi-2 protein is the central component of the recently isolated NuRD nucleosome remodelling and histone deacetylase complex. Although the NuRD complex has been the subject of extensive biochemical analyses, little is known about its biological function. Here we show that the two C. elegans Mi-2 homologues, LET-418 and CHD-3, play essential roles during development. The two proteins possess both shared and...
Topics
- Adenosine Triphosphatases
- Animals
- Animals, Genetically Modified
- Autoantigens
- Base Sequence
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Differentiation
- DNA Helicases
- DNA Primers
- Female
- Genes, Helminth
- Helminth Proteins
- Membrane Proteins