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Article

Neurophysiological defects and neuronal gene deregulation in Drosophila mir-124 mutants.

PLoS genetics - 1 Feb 2012

Sun Kailiang, Westholm Jakub Orzechowski, Tsurudome Kazuya, Hagen Joshua W, Lu Yubing, Kohwi Minoree, Betel Doron, Gao Fen-Biao, Haghighi A Pejmun, Doe Chris Q, Lai Eric C

Abstract excerpt

miR-124 is conserved in sequence and neuronal expression across the animal kingdom and is predicted to have hundreds of mRNA targets. Diverse defects in neural development and function were reported from miR-124 antisense studies in vertebrates, but a nematode knockout of mir-124 surprisingly lacked detectable phenotypes. To provide genetic insight from Drosophila, we deleted its single mir-124 locus and found...

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PMID: 22347817
DOI: 10.1371/journal.pgen.1002515
PMCID: PMC3276548

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