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Article

The potential of DISC1 protein as a therapeutic target for mental illness.

Expert opinion on therapeutic targets - 1 Jun 2016

Sawa Akira, Ishizuka Koko, Katsanis Nicholas

Abstract excerpt

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Topics

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Share to DISC1 gene
Share to Gene Expression Regulation
Share to Genetic Predisposition to Disease
Share to Mental Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26810812
DOI: 10.1517/14728222.2016.1146694
PMCID: PMC5476421

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The potential of DISC1 protein as a therapeutic target for mental illness.PMID 26810812Read ↗

DISC1 at 10: connecting psychiatric genetics and neuroscience.Semantic proximity Read ↗

DISCopathies: brain disorders related to DISC1 dysfunction.Semantic proximity Read ↗

DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to SullivanSemantic proximity Read ↗

How has DISC1 enabled drug discovery?Semantic proximity Read ↗

Linking neurodevelopmental and synaptic theories of mental illness through DISC1.Semantic proximity Read ↗

DISC1 genetics, biology and psychiatric illnessSemantic proximity Read ↗

Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondriaSemantic proximity Read ↗

A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations.Semantic proximity Read ↗

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and functionSemantic proximity Read ↗

Understanding the role of DISC1 in psychiatric disease and during normal development.Semantic proximity Read ↗

Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Key Regulator Unifying Neurodevelopment and Synaptic FunctionSemantic proximity Read ↗

Mitochondrial roles of the psychiatric disease risk factor DISC1.Semantic proximity Read ↗

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