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Article

Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance.

PLoS computational biology - 1 Jan 2016

Ogbunugafor C Brandon, Wylie C Scott, Diakite Ibrahim, Weinreich Daniel M, Hartl Daniel L

Abstract excerpt

The adaptive landscape analogy has found practical use in recent years, as many have explored how their understanding can inform therapeutic strategies that subvert the evolution of drug resistance. A major barrier to applications of these concepts is a lack of detail concerning how the environment affects adaptive landscape topography, and consequently, the outcome of drug treatment. Here we combine empirical...

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PMID: 26808374
DOI: 10.1371/journal.pcbi.1004710
PMCID: PMC4726534

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DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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