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The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant Plasmodium falciparum.

eLife - 7 Jul 2022

Masserey Thiery, Lee Tamsin, Golumbeanu Monica, Shattock Andrew J, Kelly Sherrie L, Hastings Ian M, Penny Melissa A

Abstract excerpt

The effectiveness of artemisinin-based combination therapies (ACTs) to treat Plasmodium falciparum malaria is threatened by resistance. The complex interplay between sources of selective pressure-treatment properties, biological factors, transmission intensity, and access to treatment-obscures understanding how, when, and why resistance establishes and spreads across different locations. We developed a disease...

Topics

Artemisinins
Combined Modality Therapy
Genotype
Humans
Malaria, Falciparum
Plasmodium falciparum

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35796430
DOI: 10.7554/eLife.77634
PMCID: PMC9262398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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