Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fitness landscapes emerging from pharmacodynamic functions in the evolution of multidrug resistance.

Journal of evolutionary biology - 1 May 2014

Engelstädter J

Abstract excerpt

Adaptive evolution often involves beneficial mutations at more than one locus. In this case, the trajectory and rate of adaptation is determined by the underlying fitness landscape, that is, the fitness values and mutational connectivity of all genotypes under consideration. Drug resistance, espe...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteria
Share to Bacterial Physiological Phenomena
Share to Biological Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Interactions

Share to Drug Resistance, Multiple

Share to Genetic Fitness

Share to Models, Biological

Share to Mutation

Source

Identifiers

PMID: 24720850
DOI: 10.1111/jeb.12355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24720850-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fitness landscapes emerging from pharmacodynamic functions in the evolution of multidrug resistance.PMID 24720850Read ↗

Environmental modulation of global epistasis in a drug resistance fitness landscape.Semantic proximity Read ↗

Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance.Semantic proximity Read ↗

Predictable properties of fitness landscapes induced by adaptational tradeoffs.Semantic proximity Read ↗

Metabolic fitness landscapes predict the evolution of antibiotic resistance.Semantic proximity Read ↗

Analysis of the evolution of resistance to multiple antibiotics enables prediction of the Escherichia coli phenotype-based fitness landscape.Semantic proximity Read ↗

Environmental selection and epistasis in an empirical phenotype-environment-fitness landscape.Semantic proximity Read ↗

Diverse mutant selection windows shape spatial heterogeneity in evolving populations.Semantic proximity Read ↗

Escaping an evolutionary lobster trap: drug resistance and compensatory mutation in a fluctuating environment.Semantic proximity Read ↗

Positive epistasis drives the acquisition of multidrug resistance.Semantic proximity Read ↗

Diverse mutant selection windows shape spatial heterogeneity in evolving populationsSemantic proximity Read ↗

Exploring the complexity of the HIV-1 fitness landscape.Semantic proximity Read ↗

Price equation captures the role of drug interactions and collateral effects in the evolution of multidrug resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.