Article
Functional annotation of rare gene aberration drivers of pancreatic cancer.
Nature communications - 25 Jan 2016
Tsang Yiu Huen, Dogruluk Turgut, Tedeschi Philip M, Wardwell-Ozgo Joanna, Lu Hengyu, Espitia Maribel, Nair Nikitha, Minelli Rosalba, Chong Zechen, Chen Fengju, Chang Qing Edward, Dennison Jennifer B, Dogruluk Armel, Li Min, Ying Haoqiang, Bertino Joseph R, Gingras Marie-Claude, Ittmann Michael, Kerrigan John, Chen Ken, Creighton Chad J, Eterovic Karina, Mills Gordon B, Scott Kenneth L
Abstract excerpt
As we enter the era of precision medicine, characterization of cancer genomes will directly influence therapeutic decisions in the clinic. Here we describe a platform enabling functionalization of rare gene mutations through their high-throughput construction, molecular barcoding and delivery to cancer models for in vivo tumour driver screens. We apply these technologies to identify oncogenic drivers of...
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