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Article

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets.

Nature communications - 9 Apr 2015

Witkiewicz Agnieszka K, McMillan Elizabeth A, Balaji Uthra, Baek GuemHee, Lin Wan-Chi, Mansour John, Mollaee Mehri, Wagner Kay-Uwe, Koduru Prasad, Yopp Adam, Choti Michael A, Yeo Charles J, McCue Peter, White Michael A, Knudsen Erik S

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and insights into both disease etiology and targeted intervention are needed. A total of 109 micro-dissected PDA cases were subjected to whole-exome sequencing. Microdissection enriches tumour cellularity and enhances mutation calling. Here we show that environmental stress and alterations in DNA repair genes associate with distinct mutation spectra....

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Identifiers

PMID: 25855536
DOI: 10.1038/ncomms7744
PMCID: PMC4403382

Genes

KRAS
BRAF
MYC
RBM10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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